An unprecedented wealth of data is being generated by genome sequencing projects and other experimental efforts to determine the structure and function of biological molecules. The demands and opportunities for interpreting these data are expanding rapidly. Bioinformatics is the development and application of computer methods for management, analysis, interpretation, and prediction, as well as for the design of experiments. Machine learning approaches (e.g., neural networks, hidden Markov models, and belief networks) are ideally suited for areas where there is a lot of data but little theory, which is the situation in molecular biology. The goal in machine learning is to extract useful information from a body of data by building good probabilistic models—and to automate the process as much as possible.
In this book Pierre Baldi and Søren Brunak present the key machine learning approaches and apply them to the computational problems encountered in the analysis of biological data. The book is aimed both at biologists and biochemists who need to understand new data-driven algorithms and at those with a primary background in physics, mathematics, statistics, or computer science who need to know more about applications in molecular biology.
This new second edition contains expanded coverage of probabilistic graphical models and of the applications of neural networks, as well as a new chapter on microarrays and gene expression. The entire text has been extensively revised.
An unprecedented wealth of data is being generated by genome sequencing projects and other experimental efforts to determine the structure and function of biological molecules. The demands and opportunities for interpreting these data are expanding rapidly. Bioinformatics is the development and application of computer methods for management, analysis, interpretation, and prediction, as well as for the design of experiments. Machine learning approaches (e.g., neural networks, hidden Markov models, and belief networks) are ideally suited for areas where there is a lot of data but little theory, which is the situation in molecular biology. The goal in machine learning is to extract useful information from a body of data by building good probabilistic models—and to automate the process as much as possible.
In this book Pierre Baldi and Søren Brunak present the key machine learning approaches and apply them to the computational problems encountered in the analysis of biological data. The book is aimed both at biologists and biochemists who need to understand new data-driven algorithms and at those with a primary background in physics, mathematics, statistics, or computer science who need to know more about applications in molecular biology.
This new second edition contains expanded coverage of probabilistic graphical models and of the applications of neural networks, as well as a new chapter on microarrays and gene expression. The entire text has been extensively revised.
In celebration of Caribbean American Heritage Month in June, we are sharing a collection of books by Caribbean American and Caribbean authors that includes fiction, memoir, non-fiction, and history. Find a full collection of titles here.
On Monday, May 5, three Penguin Random House authors were honored with a Pulitzer Prize. Established in 1917, the Pulitzer Prizes are the most prestigious awards in American letters. To date, PRH has 143 Pulitzer Prize winners, including William Faulkner, Eudora Welty, Josh Steinbeck, Ron Chernow, Anne Applebaum, Colson Whitehead, and many more. Take a look at our 2025 Pulitzer Prize
In June, we celebrate Black Music Appreciation month and the influential Black musicians and artists who have brought entertainment to their communities and beyond, and inspired others to make their own art. Collection of titles for Black Music Appreciation Month
In June we celebrate Lesbian, Gay, Bisexual, Transgender, Queer, Intersex, and Asexual + (LGBTQIA+) Pride Month, which honors the 1969 Stonewall riots in Manhattan. Pride Month is a time to both celebrate the accomplishments of those in the LGBTQ+ community and recognize the ongoing struggles faced by many across the world who wish to live
